Received: from localhost ([::1]:51857 helo=stodi.digitalkingdom.org) by stodi.digitalkingdom.org with esmtp (Exim 4.76) (envelope-from ) id 1Tx9Xz-0000wS-N6; Sun, 20 Jan 2013 21:03:51 -0800 Received: from cdptpa-omtalb.mail.rr.com ([75.180.132.120]:58924) by stodi.digitalkingdom.org with esmtp (Exim 4.76) (envelope-from ) id 1Tx9Xs-0000wI-DN for jbovlaste@lojban.org; Sun, 20 Jan 2013 21:03:48 -0800 X-Authority-Analysis: v=2.0 cv=LNHkseq9 c=1 sm=0 a=sqYj6zCFaLTNQ95sbP+eeQ==:17 a=W3V8cEvdJLQA:10 a=JFaJvMoBDvMA:10 a=ngmzhCly62MA:10 a=Yr05hP5UdKEA:10 a=kj9zAlcOel0A:10 a=JNFw9bs7AAAA:8 a=M2DoeeCd4RYA:10 a=FCGVxi5Bc1GPgCUmEywA:9 a=CjuIK1q_8ugA:10 a=sqYj6zCFaLTNQ95sbP+eeQ==:117 X-Cloudmark-Score: 0 X-Authenticated-User: X-Originating-IP: 69.132.98.107 Received: from [69.132.98.107] ([69.132.98.107:60939] helo=chausie) by cdptpa-oedge02.mail.rr.com (envelope-from ) (ecelerity 2.2.3.46 r()) with ESMTP id A2/1F-01431-E2CCCF05; Mon, 21 Jan 2013 05:03:43 +0000 Received: from caracal.localnet (localhost [127.0.0.1]) by chausie (Postfix) with ESMTP id 7ADA74209 for ; Mon, 21 Jan 2013 00:03:42 -0500 (EST) From: Pierre Abbat To: jbovlaste@lojban.org Date: Mon, 21 Jan 2013 00:03:37 -0500 Message-ID: <1383085.hAMHNW2WL5@caracal> User-Agent: KMail/4.8.5 (Linux/3.2.0-35-generic; KDE/4.8.5; x86_64; ; ) In-Reply-To: References: <3185684.p7HcNfvyA7@caracal> MIME-Version: 1.0 X-Spam-Score: 0.0 (/) X-Spam_score: 0.0 X-Spam_score_int: 0 X-Spam_bar: / Subject: Re: [jbovlaste] SNP, RFLP, allele X-BeenThere: jbovlaste@lojban.org X-Mailman-Version: 2.1.14 Precedence: list Reply-To: jbovlaste@lojban.org List-Id: List-Unsubscribe: , List-Archive: List-Post: List-Help: List-Subscribe: , Content-Type: text/plain; charset="us-ascii" Content-Transfer-Encoding: 7bit Errors-To: jbovlaste-bounces@lojban.org On Sunday, January 20, 2013 21:33:36 Eitan Postavsky wrote: > SNP: If you don't mind my suggesting an entirely different veljvo, I think > the key word is {panra}. An SNP is a terpanra be lo jgina bei lo jgina, > y'see? So is a RFLP, if I understand you right. And neither has to be in a gene. > RFLP: Are you referring to the difference between homologous DNA molecules > or the laboratory technique? Oh well, I don't understand either. I'm referring to a site on a chromosome where different alleles differ in the distance between consecutive occurrences of some sequence. It could be a variable-length repetition; it could be a SNP where one of the alleles is in the sequence. > Allele: ginpanra. It's two jgina that panra each other, not differing in > their terjgina. I'm aware that you're thinking of an allele as a particular > sequence of base pairs that implements a given terjgina, but ginpanra works > too, doesn't it? Let's take a concrete example: OPN1LW. I was looking that up because I have some mutation of it. OPN1LW codes for the protein which combines with something to make it see red. It has seven SNPs (one is listed as "deleted"), each of which may cause some change to the protein. There are three phenotypes in men and four in women (it's on X): normal red vision, tetrachromacy (only in women), protanopia, and protanomalopia. There are three alleles distinguishable without looking at the SNPs: normal, missense causing protanomalopia, and nonsense causing protanopia. I can't tell which SNP is which from SNPedia, because it says "protan", and I don't know whether it means protanopia, protanomalopia, or both. la'o .gin. OPN1LW .gin. jgina lo remna lo jei je ka viska lo xunre Let's denote the three alleles by R, R', and r. I'd like to say: la'o zoi. R' .zoi la'o .gin. OPN1LW lo ka frica viska lo xunre or with x2 and x3 exchanged. Pierre -- gau do li'i co'e kei do _______________________________________________ jbovlaste mailing list jbovlaste@lojban.org http://mail.lojban.org/mailman/listinfo/jbovlaste