Received: from nobody by stodi.digitalkingdom.org with local (Exim 4.92) (envelope-from ) id 1iLV40-00048y-1A for lojban-newreal@lojban.org; Fri, 18 Oct 2019 09:25:16 -0700 Received: from [64.57.93.21] (port=58815 helo=quebec.coastalconcreteforms.com) by stodi.digitalkingdom.org with esmtp (Exim 4.92) (envelope-from ) id 1iLV3x-00047I-Ew for lojban@lojban.org; Fri, 18 Oct 2019 09:25:15 -0700 DKIM-Signature: v=1; a=rsa-sha1; c=relaxed/relaxed; s=xjz; d=coastalconcreteforms.com; h=Message-ID:Reply-To:To:From:MIME-Version:Subject:Content-Type:Date; i=gwd@coastalconcreteforms.com; bh=ZobcgzPtaUtu3Uu490tvSBsixOA=; b=lIrKGDGNxQg9cv90uunzEZu9nP/rX60HLdgvs8QBwVzMHyo5eknapJPEPsGfHVyHBomumZPKHMnB gPVp+BZEVpjSBDx9m/jXHKWkqTU1TtaQqC/2PQMxxEnn1YKqLCnShvtNbZKboW5f9WokuZqdiE0x A13Zto3Dqj2PrEAiprU= Message-ID: Reply-To: gwd@coastalconcreteforms.com To: lojban@lojban.org From: GWD MIME-Version: 1.0 Subject: =?UTF-8?B?QWRqdXN0YWJsZSBSZWFkaW5nIEdsYXNzZXMsIDEvMiBPZmY=?= Content-Type: multipart/alternative; boundary="___ywdhOyoXJBG=89116-:-+?" Date: Fri, 18 Oct 2019 12:28:11 -0400 X-Spam-Score: -1.3 (-) X-Spam_score: -1.3 X-Spam_score_int: -12 X-Spam_bar: - --___ywdhOyoXJBG=89116-:-+? Content-type: text/plain; charset="UTF-8" Content-transfer-encoding: 8bit Check out these custom focus glasses. Background: ------------------------------------------------------------ Increased consumption of lutein and zeaxanthin has been shown to increase macular pigment optical density (MPOD) in some individuals. Most interventions either obtained infrequent measures of MPOD (https://www.ncbi.nlm.nih.gov/pubmed/17584283) or measured MPOD at a single retinal locus. Purpose: ------------------------------------------------------------ The aim of this study was to measure acute changes in MPOD at four retinal loci during lutein intervention. Methods: ------------------------------------------------------------ For 120 days, three subjects consumed 30 mg of lutein and 2.7 mg of zeaxanthin supplement per day. MPOD was measured with heterochromatic flicker photometry at 20', 30', 60' and 120' eccentricity three or four times per week. High-performance liquid chromatography was used to measure serum carotenoid concentrations in blood samples collected at baseline and at 30-day intervals. Results: -------------------------------------------- At the two most central loci, MPOD significantly increased in all three subjects with a mean change of approximately 0.09 log units at 20' eccentricity and 0.08 log units at 30' eccentricity. MPOD significantly increased in two subjects at 60' eccentricity, and in one subject at 120' eccentricity. The increases in MPOD appeared to be linear and continued after treatment was ended. In all three subjects, log sensitivity at the reference locus decreased linearly. Serum lutein and serum zeaxanthin increased from baseline, reaching peak concentrations after 30 days of supplementation. Conclusion: ----------------------------------------- The changes in MPOD suggest that carotenoid deposition occurs linearly and may be biased towards the central retina. Further, carotenoid deposition may occur outside the central fovea in interventions with pharmacological doses of carotenoid, resulting in underestimations of psychophysical measures of MPOD. Lutein and Zeaxanthin Carotenoids and Their Role in Eye Health. More on this topic (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705341/) . Caring for Your Eyes. Possible role for lutein and zeaxanthin (https://www.ncbi.nlm.nih.gov/pubmed/19019038) in visual development. [GWD] Abstract ------------------------------------------------------- The possibility that the macular carotenoids, lutein (L), and zeaxanthin (Z), could retard age-related changes in the eye and prevent the eye diseases that result from such changes (namely, cataract and macular degeneration) has been carefully studied. A role for the carotenoids very early in life, however, has received far less attention. Nevertheless, an influence on visual development is likely. Retinal L and Z, for instance, would influence the development of the visual system if they 1) altered input during a critical/sensitive period of visual development and/or 2) influenced maturation (https://www.ncbi.nlm.nih.gov/pubmed/17552428) and/or 3) protected the retina during a period when it was particularly vulnerable. The available evidence indicates that the pigments may play a role in all three of these areas. http://www.coastalconcreteforms.com/e/word-of-the-day/ http://ww1.coastalconcreteforms.com/e/word-of-the-day/erumpent-2019-10-17/ by accomplished foreign service officers ?pompeo?s worst nightmare.? > > now,. unranked that?s the professional league dude, amateur also exists. and marriage is a. http://public.coastalconcreteforms.com/browse/flagitious Evaluation of macular pigment optical density following femtosecond laser-assisted cataract surgery. Author Information (https://www.ncbi.nlm.nih.gov/pubmed/31190725) --___ywdhOyoXJBG=89116-:-+? Content-Type: text/html; charset="UTF-8" Content-transfer-encoding: 8bit GWD
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BACKGROUND:

Increased consumption of lutein and zeaxanthin has been shown to increase macular pigment optical density (MPOD) in some individuals. Most interventions either obtained infrequent measures of MPOD or measured MPOD at a single retinal locus.

PURPOSE:

The aim of this study was to measure acute changes in MPOD at four retinal loci during lutein intervention.

METHODS:

For 120 days, three subjects consumed 30 mg of lutein and 2.7 mg of zeaxanthin supplement per day. MPOD was measured with heterochromatic flicker photometry at 20', 30', 60' and 120' eccentricity three or four times per week. High-performance liquid chromatography was used to measure serum carotenoid concentrations in blood samples collected at baseline and at 30-day intervals.

RESULTS:

At the two most central loci, MPOD significantly increased in all three subjects with a mean change of approximately 0.09 log units at 20' eccentricity and 0.08 log units at 30' eccentricity. MPOD significantly increased in two subjects at 60' eccentricity, and in one subject at 120' eccentricity. The increases in MPOD appeared to be linear and continued after treatment was ended. In all three subjects, log sensitivity at the reference locus decreased linearly. Serum lutein and serum zeaxanthin increased from baseline, reaching peak concentrations after 30 days of supplementation.

CONCLUSION:

The changes in MPOD suggest that carotenoid deposition occurs linearly and may be biased towards the central retina. Further, carotenoid deposition may occur outside the central fovea in interventions with pharmacological doses of carotenoid, resulting in underestimations of psychophysical measures of MPOD.

   

Author Information
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