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Nature's own marvelous nanoscale machines include motors that spin bacterial flagella at up to 1000 revolutions per second and polymerases that step along DNA and RNA to facilitate the flow of genetic information. Block, along with other Stanford researchers such as Professors W. E. Moerner (Chemistry) and Steve Chu (Physics), are studying Nature's machines through single molecule science. This young field is devoted to following molecules one at a time rather than observing their averaged behavior, as has been done traditionally. To understand why average properties may obscure molecular behavior, "Consider a ship traveling from New York to San Francisco," says Block. "If it's small enough, it will travel down into the Caribbean and go across the Panama Canal and then back up to San Francisco. If it's a big oil tanker, it won't fit through the Panama Canal; it's got to go all the way around Cape Horn. But the average path of a ship traveling from New York to San Francisco would probably come out somewhere in the middle of the Amazon where there is in fact no route at all!"

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A decade ago, Saraswat's research group was the first to begin developing a new kind of chip architecture: the 3-dimensional integrated circuit (3-D IC). Compared to the 2-D planar chips in computers today, 3-D chips can provide the same processing power with a reduced chip surface area. Also, instead of having long, twisting highways of wires, the stacked chips in 3-D ICs allow for short wires much like elevator shafts, as Professor Chidsey puts it-mitigating the problem of delay in the wires. Moreover, 3-D IC architecture allows the integration of all kinds of chips, since chips that require different technologies or materials can be stacked together.
Nature's own marvelous nanoscale machines include motors that spin bacterial flagella at up to 1000 revolutions per second and polymerases that step along DNA and RNA to facilitate the flow of genetic information. Block, along with other Stanford researchers such as Professors W. E. Moerner (Chemistry) and Steve Chu (Physics), are studying Nature's machines through single molecule science. This young field is devoted to following molecules one at a time rather than observing their averaged behavior, as has been done traditionally. To understand why average properties may obscure molecular behavior, "Consider a ship traveling from New York to San Francisco," says Block. "If it's small enough, it will travel down into the Caribbean and go across the Panama Canal and then back up to San Francisco. If it's a big oil tanker, it won't fit through the Panama Canal; it's got to go all the way around Cape Horn. But the average path of a ship traveling from New York to San Francisco would probably come out somewhere in the middle of the Amazon where there is in fact no route at all!"
Sizing Up Nanotechnology by Kristine Mak Yu The backtracking movement of RNA polymerase can be followed using optical tweezers.