As much as possible, yes. Since it's meant for people who have little to no Lojban knowledge, it either can't be, our would extremely difficult to, put in entirely, exclusively, Lojban.
That said, the more of it that is in Lojban, the better. Most foreign language teachers in my experience establish a "only this language is allowed in this class" rule. The comic's class should have that rule as soon as the characters are able to say a complete bridie. Even one as simple as {mi pendo}.
There are two reasons for this. One, the more Lojban readers (and characters) are exposed to the language the more quickly and easily they will acquire it. You do need to be careful not to do anything too complex, however. Two, the less non-Lojban in the comic, the Leeds translating work needs to done for non-English nintadni.
to pu benji ti fo lo mi me la.android. samcku toi
mu'o mi'e.aionys.
My suggestion is to also publish the comic in lojban.
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